Synthesis of New Heterocyclic Derivatives of Phenothiazine | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 23, Issue 7, October 2012, Pages 75-84 | ||
| Author | ||
| Souad J. Lafta | ||
| Abstract | ||
| In this study was synthesized new phenothiazine derivatives for their potent biological activities, from compounds phenylhydrazine (1) & compound (2), as starting materials. The route of preparation involved the refluxing of compounds (1) & (2) with p-hydroxy benzaldehyde in absolute ethanol to form Schiff bases (3) & (4) , which on cyclization by mercaptoacetic acid yielded thiazolidine derivatives (5) and (6) respectively, reaction of the heterocyclic derivatives (5&6) with p-substituted anilines in presence of anhydrous zinc chloride gave substituted diarylamines (7&8)a-c . The fusion of diarylamines with sulphur in presence of catalytic amount of iodine resulted in the substituted phenothiazines (9&10)a-c . The structure of all the synthesized compounds have been supported by their physical properties and spectral data . | ||
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