Synthesis and Characterization of (Oxazepine,Diazepine,Tetrazole) for Derivatives of Sulfamethoxazole Drug | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 4, December 2012, Pages 84-96 | ||
| Author | ||
| Abstract | ||
| The present work involved synthesis of serval new substituted (Oxazepine,Diazepine and tetrazole via Schiff bases for selfamethoxazole drug by four steps. The first step involved preparation Schiff bases (A1-A5) by condensation of selfamethoxazole drug with many substituted ketones,then ,the second step include ,preparation new five oxazepines compounds (B1-B5) by reaction of phthalic anhydrid with the prepared Schiff bases in first step . The third step including reacting compounds (B1-B5) which prepared in the second step with primary oramatic amines to give new five Diazepine compounds (C1-C5) . Finally the fourth step, preparation new tetrazole derivatives D1-D5 by reaction of the prepared Schiff bases (in the first step) with sodium azide in THF. The prepared compounds were characterized by physical properties ,(FT-IR,UV. and some of them by 1H-NMR , 13C-NMR spectroscopy) were recorded and the biological activity was evaluated against two kinds of bacteria gram positive and gram negative. | ||
| Keywords | ||
| sulfamethoxzale drug; Schiff bases; oxazepine; Diazepine tetrazole | ||
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