Effect of Pimpinella anisum and Foeniculum vulgare Seeds Extracts in Protect From Oxidative Stress Induced By Hydrogen Peroxide in Swiss Albino Mice | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 3, September 2012, Pages 60-66 | ||
| Abstract | ||
| This study was conducted the effect of two plants : Foeniculum vulgare and piminella anisum as antioxidant from oxidative stress after treated with 0.5% hydrogen peroxide (H2O2) in swiss albino mice with (3) months age . mice were divided in to four groups (12 mice / group ). The mice were given drinking water containing the two plants above (750 mg / gm body weight). All groups were treated daily for aperiod of (30) days for each plant . The parameters had been depending include lipoproteins and activity of Glutathion-s-transferase and peroxidase as markers for oxidative injury .The results showed the treatment with H2O2 (0.5%) causes asignificant increase p≤0.05) in total cholesterol (TC) and triglycerides (TG) , and significant decrease (p≤ 0.05) in high density lipoprotein (HDL-C) , Low density Lipoprotein (LDL-C) , very low density lipoprotein (VLDL-C) and Atherogenic index in male and female . Treatment with Foeniculum Vulgare and Piminella anisum showed significant increase (p≤0.05) in all parameters (types of lipoproteins ) in male and female comparing to the control and group treatment with H2O2 The result showed significant decreas (p≤0.05) in glutathion-s- transferase in mice (male and female ) were treated with H2O2 , while the treatment with Foeniculum Vulgare lead to significant decrease in enzyme activity , but the treatment with pimpinella anisum lead to significant increase in enzyme activity in female only and significant increase (p≤0.05) in peroxidase activity for all treatment that employed in male and female comparision to control . | ||
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