The prevalence of thyroiditis and celiac disease in a sample of type one diabetic iraqi children | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 18, Issue 182, June 2012, Pages 269-278 | ||
| Authors | ||
| Noaman Abdulateef Abdulrazzaq; Mohammed Essa; Abdulmotaleb Abdulkareem | ||
| Abstract | ||
| The prevalence of Celiac disease(CD) ,Thyroiditis in 120 Iraqi child and adolescence with type one diabetes (T1DM),age 2-18year old, with 67male(55.83%) and 53 femal(44.16%),selected from Almansor Hospital for children,their serum samples were analyzed in the immunology and biochemistry departments of the Central public health laboratory in Baghdad to detect any significant antibodies titer related to T1DM,CD,and thyroiditis .The percents of autoimmune T1DM,CD, Thyroditis were found to be 70.83%,15.83%,9.16% respectively. Celiac disease (CD) is one of the most frequent autoimmune disorders occurring in T1DM, the clinical presentation of CD in T1DM is classified as Symptomless in approximately half of cases, but a more accurate analysis often discloses a wide array of symptoms suggestive of CD. . The thyroid is a frequent target of autoimmune problem,Hashimoto's thyroiditis and Graves' disease are two of the most common autoimmune diseases.Recently Autoimmune polyendocrine Syndromes (APS), also referred to as Autoimmune Polyglandular Syndromes, are a family of diseases that involve several endocrine organs becoming deficient as a result of the failure of the immune system to properly distinguish between self and enemy. Patients with APS are diagnosed based on the co-occurrence of several diseases, such as T1DM disease, thyroiditis, CD, and others which taken together indicate that there has been a large scale failure of the immune system. The three conditions shows the same genetic background. screening for CD, thyroditis, should be performed in all T1DM patients by means of tissue transglutaminase auto-Ab(anti-t TG auto- Abs) , antigliadin autoantibody(antiGL Abs), antithyroid-peroxidas-autoantibody (antiTPO), antithyroglobulin-autoantibody-(antiTG).while,T1DM-autoAb(anti-insulin,anti-glutamic-acid-decarboxylase'anti-GAD',anti-pancrease,anti-tyrosine-phosphatase-autoantibody'anti-IA2'). T3, T4, & TSH measurements revealed abnormal values in 24 samples where only three of them showing increased antiTG, antiTPO antibodies Objectives ;To shade a light on the prevalence of thyroiditis and celiac disease in 120 diabetic type one Iraqi children .SETTING; Central public health laboratory(CPHL)-Iraqi ministry of Health. Patients & Methods; 12O diabetic type 1child and young adolescents from almansor hospital( aged 2-18year with 67male and 53 female)were screened for DM,CD, Thyroiditis autoantibodies titers using ELISA-system except for antipancrease autoantibody in which we used IFAT principal. T3,T4,TSH were measured in all samples using radioimmuno assay principal through gamma counter system. Results; From 120, only 91 samples shows positive autoantibodies (62 of DM,13of both DM and CD,9 of both DM and Thyroiditis, one for DM'CD' and Thyroiditis,5 for CD only, and in the last sample we found only autoantibodies concerned with thyroiditis). The remaining 29 cases doesn't explore any antibodies. Conclusion; There are an increased association of autoimmune disorders among T1DM. | ||
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