P53 over-expression in urothelial carcinoma of the bladder: An Immunohistochemical Study | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 18, Issue 182, June 2012, Pages 189-211 | ||
| Authors | ||
| Karam Turath Tawfeeq; Shuaib H. S. Al-Talib | ||
| Abstract | ||
| Objectives: The aim of this study is, to evaluate the frequency of p53 over-expression in urothelial carcinoma of the bladder, to correlate the over-expression with age and sex of the patients, and grade and stage of the tumor, and to compare the results with those of others. Methods: The study was performed on 50 bladder cancers. Samples were obtained in a prospective and retrospective fashions (case series study). The samples were collected from Al-Jumhuri Teaching Hospital, during a period of 8 months from July 2011 through February 2012. Results: The patients' age was in the range of 23 to 91 years with a mean of 62.64 year. Most of them were in the seventh decade (42%). P53 immunoreactivity was observed in 34% of the total cases, it was positive in 7/11 of PUNLMP cases, 6/23 of low grade cases, and in 4/15 of high grade cases, and was negative in the only case of papilloma. It's positivity was observed in 7/14 of cases with Ta stage, 5/ 21 of T1 stage, in 4/ 11 of T2 stage, and in 1/ 2 of Tis stage. It was negative in the 2 cases of T4. Statistically p53 over-expression was not significantly related to the age and sex of the patients, and grade, and stage of the tumors. It was mainly found in the 7th decade of life (41.2%), in males (88.2%), in PUNLMP grade (41.2%), and in stage Ta (41.2%). Conclusions: P53 was over-expressed in 34% of urothelial carcinomas of the bladder, predominantly in PUNLMP (41.2%), followed by low grade tumors (35.3%), and high grade tumors (23.5%), while it was negative in papilloma. Statistically, p53 over-expression was neither significantly correlated with the age and sex of the patients nor with grade, or stage of the tumors. | ||
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