Renal function tests in hypertensive patients using atenolol | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 1, Issue 181, December 2012, Pages 36-47 | ||
| Authors | ||
| Batool Mohammed Ali Arafat; Ahmed Yahya Dallal Bashi | ||
| Abstract | ||
| Hypertension is strongly associated with functional and structural abnormalities that damage the kidneys, and other organs and lead to premature morbidity and death. This research is to study the renal function tests in hypertensive patients using Atenolol and comparing the results with that in newly diagnosed untreated hypertensive patient. In addition comparing these results with that of apparently normal residents living in Mosul as a control. Eighty essential hypertensive patients were included in this study. They were divided into two groups, the first group included 50 patients (called Group A), with ages ranged from 38 - 65 years with a mean of 49.86 ± 7.02 years, all were used Atenolol as antihypertensive mono therapy. The second group included 30 patients of newly diagnosed untreated hypertensive patients (called Group B), with ages ranged from 36-57 years with a mean of 44.9 years. A third group was the control group (called Group C), consisted of 30 normotensive subjects with ages ranged from 35-58 years with a mean of 45.9 years. The biochemical investigations carried were the renal function tests including serum; urea, creatinine, creatinine clearance, uric acid, sodium and potassium in addition to urine microalbuminuria. A comparison between the means of serum urea in Group B with Group C showed a significant increase. In addition, there was a significant increase in serum uric acid in Group B in comparison with Group C. Moreover, MA level was significantly higher in Groups A and B when compared with Group C or when compared with each other. The dose of Atenolol showed a significant increase for MA with increased dose. The duration of treatment also showed a significant increase for MA with increased duration of treatment. In addition, age also causes a significant increase in MA with advanced ages and a decreased Crcl in Group A. The overall analysis of the renal function tests indicate that Atenolol although has a mild undesirable effects on renal functions but it has a negative effect on protein excretion, Moreover, untreated hypertensive patients showed more signs of undesirable effects of kidney function tests than treated patients with Atenolol specially in its effect on MA excretion. | ||
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