Study of lymphocyte transformation response (LyTR) by using PHA, Con A and Pokeweed mitogens in children infected with Norovirus | ||
| journal of kerbala university | ||
| Article 1, Volume 8, Issue 4, November 2012, Pages 45-49 PDF (0 K) | ||
| Authors | ||
| imad H. Al-yassari; Abeer F. Al-rubaei | ||
| Abstract | ||
| There are several agents known to be capable of inducing blast transformation of small lymphocytes. The mitogens phytohaemagglutinin (PHA), concanavalin A (con A) and pokeweed mitogen (PWM) are good examples of such agents . In this study we used The heparinized blood from each of the 45 sample was examined for immuno-suppressive activity. peripheral blood lymphocytes stimulated with phytohemagglutin mitogen ( 100 ,150,250 µg/ml) , Concanavalin A mitogen (150 µg/ml) and Pokeweed mitogen PWM (150,300 µg/ml ) were severely reduced in acute infantile diarrhea with Norovirus Infection in comparing with acute infantile diarrhea without Norovirus Infection and control group . acute phase heparinized blood appears to block initial steps in lymphocyte transformation. | ||
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