Serum Levels of Interlukine-1Beta and Interlukine-2 in Chronic Periodontitis | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 23, Issue 3, April 2012, Pages 55-62 | ||
| Author | ||
| Batool H. Al-Ghurabei | ||
| Abstract | ||
| Chronic periodontitis is a multifactorial polymicrobial infection characterized by an inflammatory process that leads to destruction of teeth supporting tissues. Cytokines are considered to play a key role in the inflammation process in chronic periodontitis. The aim of this study was to investigate the possible role of serum IL-1β and IL-2 levels in patients with chronic periodontitis and determine its correlation with different clinical parameters of the periodontal status. Serum IL-1β and IL-2 levels were investigated in 50 chronic periodontitis patients and 25 healthy controls by enzyme-linked immunosorbent assay (ELISA). Periodontal parameters used in this study were plaque index, gingival index, probing pocket depth, clinical attachment level and bleeding on probing. The current results revealed that median serum level of IL-1β was significantly higher in patients than in healthy controls (p<0.001), whereas the serum levels of IL-2 was not observed any significant differences between two groups (p>0.05). Regarding correlation between serum cytokines and clinical periodontal parameters, serum IL-1β levels was showed significant positive correlation with each of plaque index, gingival index, probing pocket depth and clinical attachment level. Otherwise no association between serum IL-2 levels and clinical parameters of periodontitis was found. In conclusion the present results suggest that IL-1β may play an important role in pro-inflammatory response in serum of patients with chronic periodontitis. Key words: Chronic periodontitis, IL-1β, IL-2 | ||
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