Assessment and evaluation the antibacterial activity of selective cyclooxygenase-2 inhibitors: In vitro study | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 23, Issue 3, April 2012, Pages 35-44 | ||
| Author | ||
| Hayder M. Al-kuraishy | ||
| Abstract | ||
| This study elected to determine in vitro antibacterial activity of selected selective cyclooxygenase-2 inhibitor (meloxicam,celecoxib,valdicoxib and nimesulide) on 22 strains of gram positive and gram negative bacteria, which were isolated from skin and urinary tract infected patient. These bacteria were being cultured on specific optimal growth media. The antibacterial activity of selective COX-2 inhibitors determined by measuring zone of inhibition and minimal inhibitory concentration (MIC). MIC of celecoxib and meloxicam in µg/ml was ranged from 5-80µg/ml on selected bacteria compared with negative control (D.W) and for valdicoxib was 80-160µg/ml ,while nimesulide was ranged from 5-40 µg/ml .All the selected bacteria were showed sensitivity for all coxib used in this experimental study except Pseudomonas aeruginosa which showed resistant to meloxicam and valdicoxid also Klebsiella pneumoniae resist to nimesulide while Staphylococcus aureus was resist to valdicoxib . The smaller zone of inhibition showed by valdicoxib which was 2mm against Eschrichia coli ,while the larger zone of inhibition showed by nimesulide which was 24mm against Eschrichia coli. In conclusion selective cyclooxygenas (cox-2) inhibitor possess mild to moderate antibacterial activity mainly by nimesulide and little by valdicoxib . Eschrichia coli is a sensitive bacteria to all coxib . Consequently; coxib may be regarded as anti-inflammatory and antibacterial agent especially for urinary tract infection where Eschrichia coli is the major causative organism. | ||
|
Statistics Article View: 52 PDF Download: 45 |
||