Effect of Antituberculosis, (Rifampicin & Isoniazide) on Female Reproductive System Performance in Adult Rats | ||
| Kufa Journal For Veterinary Medical Sciences | ||
| Article 1, Volume 3, Issue 2, December 2012, Pages 1-7 | ||
| Author | ||
| AL-Chalaby A. S | ||
| Abstract | ||
| Abstract: A study was made of the effects of anti-tuberculosis agents (Rifampicin, Isoniazide) on female reproductive performance, (30) Adult female albino rats were used, While ( 12 ) were treated orally with Rifampicin ( 50 mg/kg ) and Isoniazide ( 25 mg/kg ) for 60 days , and reversibility of the induced effects by withdrawal of the treatment for 30 days were also investigated , as well as 6 rats served as control , Results reveled that absolute and relative weight of uterus and spleen are significantly non changed , while absolute and relative weight of the ovary decreased significantly , relative liver weight increased significantly , while Isoniazide cause significantly increased in heart weight , compared to control group, The withdrawal of Rifampicin and Isoniazide for 30 days brought about on complete recovery , Fertility was reduced significantly after both Rifampicin and Isoniazide administration for 60 days , Hence the effects of Rifampicin and Isoniazide are transient and reversible. | ||
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