Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats | ||
| Kufa Journal For Veterinary Medical Sciences | ||
| Article 1, Volume 3, Issue 2, December 2012, Pages 54-60 | ||
| Authors | ||
| Fadaa A. Ghafil; Fatimah A. Al-Zubaidi; Seher A. Almedeny | ||
| Abstract | ||
| Abstract: Aims of study : The present study was undertaken to assess the renoprotective effect of irbesartan on gentamicin induced nephrotoxicity in male rats. Materials and methods: Fifteen male adult Sprague-Dawely rats were enrolled in this study, rats were separated randomly into 3 groups, five rats in each group, the first group maintained on normal standard chow diet, served as control group. The second group received gentamicin 100 mg/kg/day, i.p for 4 weeks. The third group received gentamicin 100mg/kg/day i.p concomitantly with irbesartan 25 mg/kg/day p.o for 4 weeks. Results: Gentamicin treatment increased serum urea, creatinine and tissue malondialdehyde (MDA) significantly. Irbesartan treatment decreased serum urea, creatinine and tissue MDA significantly. Conclusion: Gentamicin induced nenephrotoxicity can be prevented by coadministration with irbesartan. | ||
| Keywords | ||
| Key wards; irbesartan; serum urea; creatinine; MDA; Renal histopathology | ||
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