Could Interleukin (IL)-6 Values be Used in the Identification of Glucose Intolerance in Obese Pediatric Population | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 25, Issue 3, September 2012, Pages 232-235 | ||
| Author | ||
| Walaa A. Al-Jedda | ||
| Abstract | ||
| Abstract Background: Adipose tissue is the source of a wide variety of molecules involved in the regulation of energy output and carbohydrate metabolism. Among these, cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6, appear to play a role in modulating insulin sensitivity in peripheral tissues and have been associated with the development of insulin resistance in adults. Aim of study: The aim of the study was to ascertain the relationship among the degree of adiposity, circulating fasting insulin levels, with plasma IL-6 in an obese child and adolescent population with or without glucose intolerance. Subjects and Materials: Eighty obese children and adolescents were studied. Plasma interleukin (IL)-6 were measured for those obese with normal oral glucose tolerance Test (OGTT), and obese with glucose intolerance. These patients were compared with eighty healthy children matched for age and sex. Results: Plasma fasting insulin concentration and HOMA (Homeostatic model assessment) were significantly higher in glucose intolerance obese patients [(28.2±14.9µIU/ml),(5.7±4.8)] compared with their results in normotolerance obese patients [(20.9±8.3µIU/ml),(4.5±2.7)] and control subjects[(14.8±6.3µIU/ml),(3.2±1.9)] (p 0.005 ,0.001) respectively, Plasma levels of (IL-6) in glucose intolerance obese patients were significantly higher (2.9±1.3 ng/ml) compared with normotolerance obese patients (2.0±1.1 ng/ml) and control subjects (1.5±0.9 ng/ml)(p 0.005). Interleukin (IL-6) was positively correlated with BMI, (r=0.37; p 0.001), waist and hip circumferences(r=0.35; r=0.33) respectively, (p 0.001), insulin levels (r=0.30; p 0.001), TG and VLDL-C (r=0.27; p 0.001) Conclusion: Plasma IL-6 appears to be involved in glucose metabolism, insulin resistance, and dyslipidemia in obese children and adolescents with glucose intolerance. | ||
| Keywords | ||
| Obese; Interleukin | ||
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