Antibacterial activity of Silver Nanoparticles Using Stem bark of Juglans regia against, Streptococcus mutans , Streptococcus. sanguis and ,Porphyromonas gingivalis | ||
| MUSTANSIRIA DENTAL JOURNAL | ||
| Article 1, Volume 9, Issue 2, December 2012, Pages 184-189 | ||
| Authors | ||
| Dr. Najah Ali Mohammed; | ||
| Abstract | ||
| Dental careis & periodontal disease ,the most widespread diseases affecting mankind ,involve the adherence of bacteria & development of biofilms on both the natural & restored tooth surface .within this context, a biofilm can be Classed as an aggregate of micro-organisms in which cell adhere to each other & to a surface. Nanotherapeutics offers the possibilitiy to control the formation of these & other oral biofilms through the use of nanoparticles with biocidal ,anti-adhesive & delivery capabilities. In this study, we investigated the antimicrobial activity of silver nanoparticles (Ag-NPs) using medicinal plant extracts (Stem bark of Juglans regia ) against, Streptococcus mutans, Streptococcus. Sanguis, and Porphyromonas gingivalis. Extracellular biosynthesis of silver nanoparticles was carried out by using medicinal plant extracts for the reduction of aqueous silver ions in short period. The silver nanoparticles formation was confirmed by the color change of plant extracts (SNPs) and further confirmed with the help of UV-Vis spectroscopy. Antimicrobial effect of Ag-NPs against, Strep.mutans, Strep. sanguis , and Porph. gingivalis was investigated by using disc diffusion method. The growth of Gram-positive Strep.mutans, Strept. sanguis (the causative agents of careis) , and Porph. Gingivalis (the causative agents of Periodontitis) were inhibited by Ag-NPs. The highest antimicrobial activity was observed against Strep. mutans (15.6mm SD± 1.6), Strept. sanguis (13.3mm SD±1.4) and the least was noticed against Porph. gingivalis (12mm SD± 1.0). It is confirmed that silver nanoparticles are capable of rendering high antibacterial efficacy and hence has a great potential in the preparation of drugs used against oral bacterial diseases. | ||
| Keywords | ||
| Key Words; Silver nanoparticles; Antimicrobial activity | ||
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