The physiohistological effect of pesticide Endosulfan 35% on sexual hormone on female rabbits and its role in Environmental pollution in marsh area south of Iraq | ||
| basrah journal of science | ||
| Article 1, Volume 30, Issue 2, October 2012, Pages 50-64 PDF (0 K) | ||
| Authors | ||
| ; Khawla B. Al-Jassim; Salih K.Majeed; Aldeen H. Jawad | ||
| Abstract | ||
| Endosulfan is an insecticide which used in illegal& misused application by fisherman as a mean of fish hunting purpose in marsh area / south of Iraq. This study was undertaken to investigate the effect of oral administration of three different doses of Endosulfan 35% on the sexual hormone level (LH, FSH& Estradiol) in addition to histological study of uterus, ovaries on female rabbits and study their effect on environment pollution. 48 mature female rabbits were randomly divided into 4 groups of equal number (12) on each as follow: first group which administered 0.9 ml NACL which act as control, the second, third , fourth groups which administered Endosulfan 35% as concentration( 0.5ml ,1ml,1.5 ml/ kg .B.W ) respectively. After 8 weeks, the one half of animals of each groups (6 rabbits) were sacrificed, the blood sample was taken for hormonal assay (LH,FSH& Estradiol) and histological examination of uterus , ovaries were done. After recovery period (5 weeks) the same parameters mention above was measured. The results showed that Endosulfan35% regarded as persistent organic pollutant caused endocrine disruptor and causing lowering of LH, FSH& Estradiol level and did not return to normal value after recovery period. Histological changes were noticed in uterus including fibrotic polyp (tumor like) in fourth group (1.5 ml ) , as well as reduce endometerium in all treated groups as compared with control group . Whereas the ovaries showed primary and secondary follicles in third and fourth groups (1ml, 1.5ml) and did not return to normal structure after recovery period. | ||
| Keywords | ||
| organic pollutant; Endocrine disrupter; Endosulfan; Histological change | ||
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