Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 25, Issue 3, September 2012, Pages 191-195 | ||
| Author | ||
| Hayder M. Al-Kuraishy | ||
| Abstract | ||
| Abstract Background: Desmopressin is a synthetic form of human vasopressin hormone act chiefly on V2 receptor that found in vascular and brain tissues ;and it's primarily used for treatment of nocturnal enuresis .Also previous studies in animals suggested that central vasopressinergic system proceed on cognitive function . Aim of study: This study aimed to estimate the central effects of desmopressin on human vigilance task and psychomotor performances in normal healthy volunteers. Subjects and method : This study done in the course of measurement of recognition reaction time (RRT); movement reaction time (MRT),total reaction time(TRT) and flickering-fusion frequency threshold which reflects the vigilance task and psychomotor performances by specific Leeds Battery Instrument before and after single trans-nasal desmopressin acetate in 20 healthy volunteers(17 males+3 females). Results: This study showed that desmopressin produced significant effects on all vigilance- psychomotor performance parameters (P<0.05) with the exception of on critical flickering which produced insignificant effects ( P >0.05). Conclusion: Desmopressin acetate significantly improves human vigilance- psychomotor performances and improves cognitive function so we recommend using this drug for nootropic effects and stimulation of mental function. | ||
| Keywords | ||
| desmopressin; psychomotor performance and critical flickering | ||
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