Isochromosome 6(p) is a rare chromosomal aberration in Acute Lymphoblastic Leukemia: A case report | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 5, Issue 2, December 2012, Pages 157-160 | ||
| Authors | ||
| Nada Abed Al-Majeed Al-Ansari; Nahi Yousif Yaseen; Noor Hashim Ismail | ||
| Abstract | ||
| Cytogenetic analysis using G- banding technique was performed on bone marrow cells from a 22-year-old female who was diagnosed with Acute Lymphoblastic Leukemia . The chromosomal analysis showed a complex karyotype which included the Isochromosome 6(p) in 16 metaphases (16%) of 97 total metaphases studied . This finding suggests a strong selective pressure for loss of heterozygosity of genes located on 6q , and is in keeping with the hypothesis that one or more tumor suppressor genes might be located on the long arm of chromosome 6 . Moreover, trisomy (or tebasomy) for the short arm of chromosome 6, due to the isochromosome formation , indicating also a possible role for amplification of genes located on 6p in tumor progression in this case of acute lymphoblastic leukemia . | ||
| Keywords | ||
| acute lymphoblastic leukemia; Isochromosome; rare chromosomal aberration | ||
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