CTLA4 gene polymorphisms associated with insulin-dependent diabetes mellitus (IDDM) type I in Iraqi population | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 5, Issue 2, December 2012, Pages 123-126 | ||
| Authors | ||
| Ismail Hussein Aziz; Abdulameer M. Ghareeb; Najwa Sh. Ahmed | ||
| Abstract | ||
| This study was correlated to evaluate polymorphisms in CTLA4 associated with insulin-dependent diabetes mellitus in a Iraqi population. Blood samples were collected from 40 patient (4-25 years) from 1/6/2010- 1/2/2011, isolation of DNA were done and PCR was performed using primer for CTLA4 gene. The result shows that 31 patients have mutation in 49 position A/G polymorphism in exon 1 of CTLA4 by using BstEII enzyme. There is a highly significant correlation between diabetes and incidence of A/G 49 position in exon 1 of CTLA4 gene (X2 = 32.1, P>0.05), the conclusion is that there is enough evidence to support the claim that diabetes is related to A/G 49 transition mutation. | ||
| Keywords | ||
| CTLA; Insulin; dependent diabetes mellitus | ||
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