The Correlation between Oxidative Stress and Thyroid Hormones in Serum and Tissue Homogenized of Hypothyroidism Patients | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 9, Issue 4, December 2012, Pages 843-849 | ||
| Authors | ||
| Saad Alfallouji; Ragaa KH. Ali; Widad J. H. Ali | ||
| Abstract | ||
| Background: Hypothyroidism is a condition resulting from insufficient production or diminished action of either T3 and/or T4 thyroid hormones. Objective: The present study is to look for a correlation between oxidative stress and thyroid function in hypothyroidism patients. Patients and Methods: 30 patients with hypothyroidism patients and 30 healthy individuals as control subjects were included in the study. We measured their serum tri-iodothyronine, thyroxin and thyroid-stimulating hormone( T3,T4,TSH ). Estimation of MAlondyIdehyd (MDA) and Glutathione (GSH) in serum and in homogenized thyroid tissue were carried out by standard methods. Results: TSH was elevated in both serum and in homogenized tissue of patients compared to controls, while T4 and T3 were significantly lower in the patients than in controls. Melanodyldehyd (MDA) aS Lipid Peroxidation were significantly higher in both serum and in homogenized tissue of patients than in the controls, while(GSH) were significantly lower in both serum and in homogenized tissue of patients than in the control subjects. Conclusions: According to the present study we could conclude that hypothyroidism cause tissues undergo several biochemical changes that predispose them to oxidative damage. Therefore we suggest that hypothyroidism patients may benefit from supplements of antioxidants. Keywords: Glutathione; Oxidative stress, thyroid gland ,.Hypothyroidism | ||
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