Formulation and In Vitro Evaluation of Mucoadhesive Antimicrobial Vaginal Tablets of Ciprofloxacin Hydrochloride | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 12, Issue 2, December 2012, Pages 200-213 | ||
| Authors | ||
| Firas Aziz Rahi; ; Lena M | ||
| Abstract | ||
| Abstract: Ciprofloxacin is a broad spectrum fluoroquinolone, effective in the treatment of a wide range of infections, including genitourinary tract infections. In this study, bioadhesive vaginal tablets of ciprofloxacin hydrochloride were prepared by direct compression method using a combination of bioadhesive polymers carbopol 934P(Cp), carboxymethylcellulose (CMC) and sodium alginate (SA) in different ratios. The prepared tablet formulations were characterized by measuring their swelling capacity, surface pH, bioadhesive properties, and in-vitro drug dissolution. It was found that the bioadhesive force was directly proportional to | ||
| Keywords | ||
| KEYWORDS; ciprofloxacin hydrochloride; carbopol; carboxymethyl cellulose; sodium alginate; vaginal drug delivery | ||
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