The Association between Thyroid Hormones and Lipid Profile in Patients with Primary Hyperthyroidism | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 9, Issue 4, December 2012, Pages 721-727 | ||
| Authors | ||
| Shahlaa K.A. Jabuk; Abdulsamie H. Alta; Khawla A. shemran; Ferdos A. Alterihy | ||
| Abstract | ||
| Abstract Background: Thyroid hormones are important at cellular level, affecting nearly every type of tissue in the body. Objectives: The present study was carried out to deter¬mine whether thyroid hormones affect lipid profile in patients with hyperthyroidism. Materials and Methods: This study was carried out on 22 hyperthyroid patients (11 men and 11 women), with mean age 48.5±13.1 years and 24 apparently healthy control (12 men and 12 wome), with mean age 49.5±11.4 years). Serum levels of, thyroid stimulated hormone TSH, thyroxine (T4) and triiodothyro¬nine (T3) were measured by ELISA technique, and total cholesterol (TC), high-density lipo-protein cholesterol (HDL-C), and Triglyceride (TG) were measured spectrophotometrically, while low-density lipoprotein cho¬lesterol (LDL-C) and very low-density lipoprotein cho¬lesterol (VLDL-C ) were calculated. Results: Thyroid stimulated hormone TSH, lipids and lipoproteins (TC, TG, HDL-C, LDL-C, VLDL-C ) levels of patients were significantly lower than those of the control group ( p> 0.05). And there were significant increases in serum thyroid hormones T4, T3 values (p > 0.05). Conclusion: Hyperthyroidism is associated with decrease levels of lipoprotein, caused by increased hepatic uptake due to an enhanced affinity for the LDL receptor, and regulatory protein of TG (ApoAV). | ||
| Keywords | ||
| Thyroid Hormones; lipid profile; Hyperthyroidism | ||
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