Acetylcholinesterase Activity, Calcium, Magnesium, and Total Antioxidant in Uncontrolled Diabetic Type 2 Patients Treated with Daonil® and Glucophage® | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 9, Issue 3, September 2012, Pages 665-683 | ||
| Authors | ||
| Oda M. Yasser; Maha F. AL-Smaism | ||
| Abstract | ||
| Abstract In this study 298 patients suffering from diabetes mellitus type 2 (150 male, and 148 female) aged between 35 to 67 years with a mean age of (45.11±12.03) were included. The study was carried out from first of November 2009 to the day 31 of May 2010.The samples were obtained from Al-Kassim hospital and Merjan Teaching Hospital in Hilla city . The study included three groups: Firstly: 149 patients with type 2 diabetes mellitus treatment with Daonil . Secondly: 149 patients with type 2 diabetes mellitus treatment with Glucophage .Thirdly: 83 apparently healthy subjects were chosen as healthy people. The results show a significant increase p<0.05 in Acetylcholinesterase AChE activity of patients treated with daonil and glocophage ≤5 years when compared with control group , while AChE activity found to be highly significant increase p<0.001 in patients treated more than five years when compared with ≤5 years and control groups. No differences were found in blood AChE activities between subgroups of each sample used in this study . Corrected total calcium and ionized concentrations in DM type 2 treated with daonil and glucophage groups ≤5 and more than five years found to were highly significantly increased p<0.001,when compared with that of the control, while there was a non-significant difference p>0.05 between the males and females when compared in the same group( control, daonil and glucophage ) in all duration. A significantly increased p<0.001 in the corrected total calcium concentration of DM patients treatment with daonil (more than five years) when compared with that of the patients treatment with glucophage . A significant increase p<0.05 in magnesium concentrations in diabetes mellitus patients (daonil, and glucophage) ≤5 years when compared to control group. On the other hand a highly significant increase p<0.001 of magnesium concentrations were found in sera of DM patients more than five years when compared to DM patients ≤5 years and control group .No significant difference were found between males and females in control group and patients groups. A significant decreased p<0.05 in total antioxidant(TAC) concentration in DM patients treatment ≤5 years with daonil and glucophage was found when compared with control groups .A highly significant increase of total antioxidant p<0.001 in sera of TCA of DM type 2 patients treated (6-15y) when compared with that of healthy control group and ≤5 years. No significant difference was found in the males and females of DM type 2 patients treated with daonil and glucophage (≤5y or 6-15 y) when compared with control group P>0.05. | ||
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