The Possible Protective Effect of Green Tea Extract against Methotrexate - Induced Liver Injury in Male Rats | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 9, Issue 3, September 2012, Pages 650-655 | ||
| Authors | ||
| A.Razzak A.Latif; Dalia Abdulzahra Muhsin | ||
| Abstract | ||
| Abstract This study was performed to evaluate the influence of simultaneous administration of aqueous green tea extract (1.5 %) with methotrexate (0.5 mg /kg) on the status of glutathione (GSH) in liver tissue, with measuring the activity of serum liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST)] and serum bilirubin levels. Administrations of aqueous green tea extract alone resulted in a significant increase in liver tissue GSH level and when it was used with MTX it ameliorated MTX-induced changes in level of this parameter. Regarding enzymes activities, administration of aqueous green tea extract resulted in an alleviating effect on MTX-induced elevation in serum ALT activity with a non-significant reduction in serum AST activity; it also significantly reduced MTX-induced elevation in total serum bilirubin level, these effects may be related to direct or indirect antioxidant property of green tea extract . | ||
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