D2-40 AS A POTENTIAL MARKER THAT DIFFERENTIATE VERRUCOUS CARCINOMA FROM SQUAMOUS CELL PAPILLOMA | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 10, Issue 3, September 2012, Pages 243-248 | ||
| Author | ||
| Bashar H Abdullah | ||
| Abstract | ||
| Background:Verrucous carcinoma is a distinct variant of oral squamous cell carcinoma characterized by slow growth and rare metastases. It may present diagnostic difficulties as it may be inaccurately diagnosed as squamous cell papilloma. Objective:The study performed a comparative immunohistochemical staining for both entities to obtain a possible method of differentiation. Methods:The study involved 13 samples of oral verrucous carcinomas and 10 samples of oral squamous cell papillomas which were stained immunohistochemically with antibodies to the lymphatic endothelial marker D240. Results:In all samples, the entire epithelium of verrucous carcinomas was positively stained with D240 whereas only the basal cell layer of squamous cell papillomas was positive. Conclusion:D240 could be used as a differentiating marker between oral verrucous carcinomas and squamous cell papillomas. Keywords:Verrucous carcinoma, Squamous cell papillomas, D240. | ||
| Keywords | ||
| Verrucous carcinoma; Squamous cell papillomas | ||
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