Preparation and evaluation of salbutamol liposomal suspension | ||
| Mustansiriya Medical Journal | ||
| Article 1, Volume 11, Issue 2, December 2012, Pages 39-44 | ||
| Author | ||
| Nidhal Khazaal Marie | ||
| Abstract | ||
| Background: Liposomes are new drug delivery systems consist of lipid bilayer membrane that encapsulate water and lipid soluble drugs. Materials and methods: Liposomal suspension was prepared using chloroform film method. Different amount of cholesterol and lecithin (100, 200, 300, 400 and 600 mg) were used and their effect on particle size, encapsulation efficiency and drug release was studied. Cholesterol used in different ratios such as (1:1, 1:2 and 2:1) for Cholesterol: Lecithin respectively to evaluate its effect on particle size, encapsulation efficiency and drug release. The effect of increasing salbutamol HCl amount from 10mg to 20mg on encapsulation efficiency was also studied. Results: The morphology of the prepared formulae showed uniform unilamellar liposomes enclosing the drug in the internal aqueous phase. The observed results of our work suggest that chloroform film method is a good alternative method for the preparation of liposomes for water soluble drugs because of its simplicity, low cost, time saving and few processing steps. Conclusions: The work suggests a formula that may improve the permeability of salbutamol HCl through mucosal membrane. | ||
| Keywords | ||
| Salbutamol liposomal suspension; Cholesterol; Lecithin | ||
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