The Relationship between Insulin Resistance and Oxidative Stress in Pre-eclamptic Women in Babylon Governorate | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 9, Issue 3, September 2012, Pages 526-544 | ||
| Authors | ||
| Dalia Sh. Al-owiadi; Tariq H. Al-Khayat; Bushra J. Al-Rubaiee | ||
| Abstract | ||
| Background: Pre-eclampsiaisa medical condition characterized by a BP of 140/90 mm Hg or greater after 20 weeks' gestation in a women with previously normal BP and who have proteinuria (≥ 0.3 g protein in 24-h urine specimen). Aim of the study: In this study, we tried to establish the relationship between insulin resistance and oxidative stress in sera of pre-eclamptic women and their effect on the clinical severity of disease. Patients and Methods: The study was conducted in Babylon Maternity and Pediatric Teaching Hospital for the period starting from April 2011 to the end of August 2011 on the fifty pre-eclamptic women [fifteen in the second trimester (G1), twenty in the third trimester (G2) with mild pre-eclampsia and fifteen patients in the third trimester with severe pre-eclampsia (G3)] .Fasting serum insulin, Fasting blood glucose , Total antioxidant level ,Lipid profile ,Malondialdehyde and uric acid were determined .Insulin resistance was calculated according to HOMA score. The results were compared with results obtained from age and BMI ̶ matched control groups which consisted of forty apparently healthy pregnant women [fifteen in the second trimester (G4) and twenty five women in the third trimester (G5)]. Results:The results of the present study revealed a significant increment in insulin resistance (IR-HOMA) in sera of (G1) compared with (G4) (P<0.05), also there was a significant increment in IR-HOMA in sera of (G2&G3) compared with control group (G5) (P<0.01),and also there was a significant increment in IR-HOMA in (G3) group compared with (G2) (P<0.01) . Serum total antioxidant status (TAS) was significantly declined in (G1,G2&G3) compared with (G4&G5) (p<0.01) and there was a significant declined in TAS seen in sera of (G3) compared with (G2) (P<0.05). Serum MDA concentration was significantly increased in (G1,G2and G3) compared to (G4 and G5) (P<0.01). Also serum MDA concentration was significantly higher in (G3) compared with (G2) (p<0.05) . S.uric acid concentration was significantly higher in (G1&G2 ) compared to (G4 and G5) (P<0.05). Also S. uric acid concentration was significantly increased in (G3) compared with (G5) (p<0.01) , and also s.uric acid was significantly higher in (G3) compared with (G2) (p <0.05). Serum TG & VLDL-c were significantly higher in (G1&G2) compared with (G4,G5) (p<0.05). Also a significant increment in TG &VLDL-c were seen in (G3) compared with (G5) (p<0.01) . There was a significant increment in previous parameters in (G3) compared with (G2) (p<0.05). No significant difference were seen in the serum levels of TC,LDL-c,HDL-c in sera of all groups.Finally no significant correlation between IR-HOMA and TAS in sera of all groups (p˃0.05), No significant correlation between IR-HOMA and S.MDA in sera of different groups p˃0.05 except in G4 there was a significant positive correlation between IR-HOMA and MDA (p<0.01) and also no significant correlation between TAS and MDA in different groups (P˃0.05) except in (G1) a significant positive correlation was seen between TAS and MDA(p<0.05). | ||
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