Evaluation of Oxidative Stress in Patients with Vitiligo in Najaf/ Iraq | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 5, Issue 12, December 2012, Pages 1446-1454 PDF (0 K) | ||
| Author | ||
| Abdulhussain J. Shamsa | ||
| Abstract | ||
| Background: It has been suggested that, in vitiligo there was a systemic imbalance of both enzymatic and non-enzymatic antioxidants which could be the source of damage of the melanocytes. Generation of reactive oxygen species and lipid peroxides is associated with this imbalance which could be the possible pathogenic factors in this hypopigmentary disorder. Objective: The aim of the present study was to determine the levels of antioxidant parameters; glutathione peroxidase (GSH-Px), glutathione (GSH), catalase (CAT) and the level of lipid peroxidation marker Malandialdehyde (MDA) in patients with vitiligo in comparison with healthy controls matched for age and sex and to correlate these levels with the activity , extent of the disease and with age and sex of the patients, aiming to clarify the role of systemic oxidative stress in pathogenesis of vitiligo. | ||
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