The association of serum Cancer antigen 125 and C-reactive protein level with the severity of preeclampsia | ||
| Kerbala Journal of Medicine | ||
| Article 19, Volume 5, Issue 11, June 2012, Pages 1322-1327 PDF (0 K) | ||
| Authors | ||
| Warqaa Mahdi Kamel; Ban Hadi Hameed; Dr.Miami Abdul Hassan Ali | ||
| Abstract | ||
| Back ground: It has been assumed that the failure in trophoblastic invasion and the induction of an inflammatory process within placenta in patients with preeclampsia may trigger the expression of Cancer antigen 125. C-reactive protein is a marker of tissue damage and inflammation, increased C-reactive protein may reflect endothelial cell dysfunction in preeclampsia and may be a potential marker of preeclampsia. Objectives: To evaluate the association of serum Cancer antigen 125 and C-reactive protein level with the severity of preeclampsia. . Patients & methods: A case control study was carried out in the department of gynecology and obstetrics at Al-Yarmouk teaching hospital (BaghdadIraq) for one year from April 2010 to March 2011. Hundred singleton pregnant women were divided into fifty patients with preeclampsia and fifty healthy pregnant women as control group. Blood samples were taken for measurement of serum cancer antigen-125 and C-reactive protein for both groups. Results :The mean level of cancer antigen-125 in mild, severe preeclampsia and eclampsia groups was 32.57±8.08(IU/ml), 38.04±9.44(IU/ml) and 47.60±12.09(IU/ml) respectively which was significantly higher in comparison to the control group (sampled at the same time) which was 13.70±8.44(IU/ml) the P value was (0.0001). The mean level of c-reactive protein in mild, severe preeclampsia & eclampsia was 15.80±6.69(mg/L), 30.64±15.66(mg/L) and 42.60±13.70(mg/L) which was significantly higher in comparison to the control group which was 7.92±4.05(mg/L) the P value was( 0.0001). Conclusion:Serum cancer antigen 125 and c-reactive protein were significantly higher in preeclampsia groups in comparison to the control group and the increment was directly correlated with the severity of preeclampsia | ||
| Keywords | ||
| Cancer antigen; reactive protein; Preeclampsia | ||
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