J. Qasir, A., A. Sadon, A. (2012). Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release. Alustath, 21(2), 24-30.
Ahlam J. Qasir; Ahmed A. Sadon. "Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release". Alustath, 21, 2, 2012, 24-30.
J. Qasir, A., A. Sadon, A. (2012). 'Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release', Alustath, 21(2), pp. 24-30.
J. Qasir, A., A. Sadon, A. Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release. Alustath, 2012; 21(2): 24-30.

Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release

Iraqi Journal of Pharmaceutical Sciences
Article 1, Volume 21, Issue 2, December 2012, Pages 24-30
Authors
Ahlam J. Qasir; Ahmed A. Sadon
Abstract
This study include design and synthesis of 2 derivatives of compounds consisting of mefenamic acid, glycine and organic nitrates (2-nitrooxy ethanol or 1,3-dinitrooxy-2-propanol). Nitric oxide NO has been reported to support many of the same mucosal protection mechanisms as prostaglandins and is sufficient for acute gastroprotection and ulcer healing. So we suppose these 2 compounds would reduce non-steroidal anti-inflammatory drugs NSAIDs gastrointestinal side effect.
Keywords
non; Steroidal anti; inflammatory drugs; Glycine; Mefenamic acid; Organic nitrates; Nitric oxide; NSAIDs
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