Bacteriocin activity investigation of Bacillus circulans in vivo and ecological factors tolerance | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 4, Issue 2, December 2012, Pages 19-31 | ||
| Author | ||
| Dr. Hakj Abdul Abass Essa | ||
| Abstract | ||
| The study aimed to investigation and identification on antagonism activity of Bacillus circulans filtrates against causative bacteria E.coli, 1n vivo. Throught the estimation of viable cells of urinary tract infection bacteria in urine and lung tissues of experimental mice , Inhibitory activity of Bacterial concentrated filtrate was investigated against E.coli bacteria .Results obtained may be summarized as follows : The result showed that the Bacillus circulans filterate (C2) resist to high acidity and bile salt (30 %) during 24 hours . and 60 c. Concentrated filtrate of Bacillus circulans showed a good antagonism activity against bacteria , when given to mice before and after infection, noticed decrease in viable count of E.coli shown in urine from (1.3 x 105) cell / ml to (1.3 x 101) of treated mice with filtrate as compared with infected mice without treated by filtrate. In addition to decrease in viable count of this bacteria in kidney tissues from (4x 105) cell / g to (1.7 x103) cell / g without appearance of any growth in filtrate treated . LD50 of concentrate bacteria filtrate when 108. So is a consider as safety treatment if given as a therputic doses . | ||
| Keywords | ||
| Bacillus circulans; coli; kidney tissues; Bacillus circulans | ||
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