STUDY OF THE RELATIONSHIP OF CagA TOXIN AND IT'S PHOSPHORYLATION SITES WITH THE OUTPUT OF DIFFERENT STRAINS OF Helicobacter pylori INFECTIONS | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 11, Issue 1, June 2012, Pages 24-37 | ||
| Abstract | ||
| ABSTRACT Helicobacter pylori causes different digestive system diseases. H.pylori has different virulence factors, among them CagA which is phosphorylated at tyrosine residue located in special motif of five amino acid "EPIYA". CagA toxin may have different number and EPIYS(s). Relationship between the CagA(s) with EPIYA or without and diseases in different countries was used by using the sequences in public databases. The analyses revealed that there is positive correlation between increasing number of EPIYA(s) and different ulcers; the correlation coefficient r reached +0.866 in peptic ulcer. The relation of EPIYA(s) number and cancer(s) showed inverse relationship as well with gastritis and unknown diseases and r values were negative (-0.421,-0.537respectively). It has been concluded that presence of motifs and their phospharylation sites are not the chief reasons for disease induction such as cancer | ||
| Keywords | ||
| Helicobacter Pylori; CagA; EPIYA; Phosphorylation; digestive system diseases | ||
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