The Synthesis of New Phenytoin Derivative and the Study of Its Inhibition Activity to Cyclooxygenase-2 (COX-2) | ||
| Journal of Basrah Researches (Sciences) | ||
| Article 1, Volume 38, Issue 4, December 2012, Pages 36-44 PDF (0 K) | ||
| Author | ||
| Usama Hamid Ramadhan | ||
| Abstract | ||
| Inflammation is the complex biological response to a protective attempt to remove the injurious stimuli, most strongly implicated are prostaglandins (PGs), leukotrienes (LTs), histamine, bradykinin, platelet activity factor (PAF) and interleukins. The Phenytoin is a drug used for the treatment of antiepileptic. Phenytoin acts to suppress the abnormal brain activity seen in seizure by reducing electrical conductance among brain cells by stabilizing the inactive state of voltage gated sodium channels, Phenytoin (5,5-diphenylimidazolidine-2,4-dione) were prepared from benzil and urea with sodium hydroxide in absolute ethanol. The derivative of phenytoin was prepared from a histidine acidifies with hydrochloric acid in absolute ethanol and phenytoin to give phenytoin-3-histdine IUPAC name is (S)-3-(2-amino-3-(1H-imidazol-4-yl) propanoyl)-5,5-diphenylimidazolidine-2,4-dione. | ||
| Keywords | ||
| Anti; inflammatory agent; Phenytoin; Phenytoin derivative; COX; inhibitor | ||
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