Pathological Effects of Anabolic Steroid (Sustanon®) on Kidney of Male Rats | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 5, Issue 1, June 2012, Pages 159-172 | ||
| Authors | ||
| E. R. Al-Kennany; E. K. Al-Hamdany | ||
| Abstract | ||
| This study was designed to detect the pathological effects of one of anabolic steroids (sustanon) in different concentrations on male rats. The experiment was conducted on 150 male rats, divided randomly into five groups each group contained 30 rats, the first group (G I) was considered as negative control in which animals were treated with diet and water only, the second group (G II) was considered as positive one in which animals were injected with sesame oil intramuscularly (IM) weekly for a period of eight weeks. Groups III, IV, and V were treated with diluted sustanon in different concentration (5, 10, 20) mg/kg respectively by IM injection weekly for eight weeks. The clinical signs was recorded weekly, blood samples were collected through the period 15, 30, 60 days, then from each groups five rats were lifted for 30 days on diet and water only to determined if these changes are progressive or irreversible. The clinical signs on animal represented by excitation, biting and production of high sounds observed inside cage at first 3 weeks and continued to a period of 6 week after treatment in all groups. While these signs disappeared at a week 7, 8 and in lifted animals for 30 days without treatment. Also the results showed significant increase in the level of urea and creatinene at a value P<0.05 in treated group as compared with control groups but it was more prominent in (G V) on a day 60 post treatment, these levels continued in increasing magnitude in animal lifted for 30 days post treatment. Pathologically all groups revealed gross and histopathological changes in kidney of animals represented by hypertrophy and greenish discoloraton. The histological sections of kidney showed acute tubular necrosis and epithelial cell swelling in some proximal and distal convoluted tubule associated with glomerular changes. These changes continued even after discontinuation of treatment with sustanon for 30 days post treatment in all treated groups. In conclusion this study showed that sustanon at a concentration of (5, 10, 20) mg/kg/BW for a periods 15, 30, 60 days have a side effects on a kidney and these effects are progressive even after lifting the animal on diet and water for 30 days post last treatment, this improved the sustanon have progressive irreversible changes. | ||
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