Spectrophotometric Assay of Iron (II) in Pharmaceutical Formulation Using Alizarin Red Sulphonate Reagent | ||
| Journal of Education and Science | ||
| Article 1, Volume 25, Issue 1, March 2012, Pages 1-10 PDF (0 K) | ||
| DOI: 10.33899/edusj.2012.59009 | ||
| Authors | ||
| Usra I. Al-Neaimy; Amal M. Saeed; Thabit S. Al-Ghabsha | ||
| Abstract | ||
| Abstract A rapid, sensitive and simple spectrophotometric method was developed for the determination of iron (II). The method was based on the reaction of iron (II) with alizarin red sulphonate reagent to form a brown chelating complex in an aqueous solution. The absorbance of the chelating complex was measured at 566 nm with a molar absorptivity of 7.8 x 103 l.mol-1.cm-1. The chelating complex conforms to Beer's law over the range (0.5-5) g.ml-1. the average recovery% was 100.06% and precision (RSD) was found to be less than 1%. The method was successfully employed for assay of iron (II) in pharmaceutical formulations (tablets and capsules). The results have been compared with British pharmacopoeia method. | ||
| Keywords | ||
| Spectrophotometric Assay of Iron (II); Pharmaceutical Formulation; Alizarin Red Sulphonate Reagent | ||
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