EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL | ||
| Basrah Journal of Veterinary Research | ||
| Article 1, Volume 11, Issue 1, June 2012, Pages 122-127 PDF (0 K) | ||
| DOI: 10.33762/bvetr.2012.54766 | ||
| Author | ||
| Mazin N. Mousa | ||
| Abstract | ||
| The aim of this study was to evaluate the anti-inflammatory and the ulcerogenic activity of 5-(3-chloro-1-benzothien -2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol. The anti-inflammatory effect of the compound was determined by comparing it with a standard drug (naproxen). The anti-inflammatory effects were studied by using carrageenan-induced paw edema method and Cotton pellet induced granuloma in rats and the ulcerogenic liability was assessed and compared with a standard drug. The results showed that the compound had an obvious anti-inflammatory effect and the activity is comparable to that of the standard drug with less ulcerogenic effects. | ||
| Keywords | ||
| Anti inflammatory; Triazole; Ulcer | ||
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