The relationship between leptin and testosterone in infertile men | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 8, Issue 1, June 2012, Pages 106-112 | ||
| Authors | ||
| Wisam Suhail Najem; Abdulla Aqeel A. Al-tayar; Sajeda Saed Al-Chalaby | ||
| Abstract | ||
| The corresponding decrease in men fertility and fecundity may be explained in parallel to obesity, and obesity may be considered as an etiology of male infertility. Leptin, the adipocyte-derived hormone that plays a key role in body weight homeostasis, has recently emerged as a relevant neuroendocrine mediator in different systems, including the reproductive axis. A case-control study was carried out to examine the relationships between leptin and testosterone hormone in males. Eighty men their ages between 20 and 45 years; fertile normozoospermia as a control (n = 28) and infertile oligozoospermia (n = 52); were recruited in the study. There was a highly significant negative correlation between testosterone and leptin. This result is suggestive of a link between the adipocyte derived hormone, leptin and male reproduction. This study showed that obesity may represent an actual threat to male fertility causing a decrease of total testosterone with hyperleptinaemia. | ||
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