Histopathological effects of exogenous melatonin on connective tissues of thymus gland in male rats | ||
| Mustansiriya Medical Journal | ||
| Article 1, Volume 11, Issue 1, June 2012, Pages 69-74 | ||
| Author | ||
| Basim Sh. Ahmed | ||
| Abstract | ||
| Background: The neurohormone namely melatonin is secreted by the pineal body in brain. It could reach all the bodily tissues and cells; affecting their function, depending on its biological level. Thymus gland is well known to be the main central immunity director, and its wellness is rather proportional to melatonin level. Aims: This work was done to study the histopathological effect of exogenous melatonin on thymic connective tissue bulk. Materials and Methods: Dietary melatonin was supplied to adult rats, for successive 30 days. Rats were divided 6 groups. Group 1 was the control, group I was the control. Group II, III, IV, V and VI were supplied with a daily measured quantity of melatonin as 125, 250, 500, and 1000 µm/kg body wt, respectively. After the last day of treatment all animals were killed then the left thymic lobe was removed under anesthesia for histopathological study. Results: No noteworthy effect of melatonin was seen on the thymic connective tissue on its normal doses, whilst it had significant effect on the connective tissue bulk with its large doses. Conclusions: The treatment of dietary melatonin had no important effects on the rat thymic connected tissues, on its little doses, but it has considerable effects when administrated in large doses. | ||
| Keywords | ||
| Connective tissue; Melatonin; and thymus | ||
|
Statistics Article View: 138 PDF Download: 70 |
||