Isolation and Identification of Phenols and an Alkaloidic Compound from Matricaria chamomilla Plant Flowers and Study of Their Medicinal Activity Against the Pathogenic Bacteria of Skin Infections | ||
| Journal of Univesity of Thi-Qar | ||
| Article 1, Volume 7, Issue 3, September 2012, Pages 1-17 | ||
| Authors | ||
| Abbas Dawwas Matter Al; | ||
| Abstract | ||
| Phenols and an alkaloidic compound were isolated from Matricaria camomilla plant flowers . The chemical and physical properties of isolated compounds were studied using qualitative tests , functional groups test , thin layer chromatography ( TLC ) and infra-red ( IR ) spectroscopy . The results showed presence of two phenolic compounds in phenols extract and one alkaloidic compound in alkaloids extract . The medicinal activity was measured against growth of standard bacterial strains of skin infections were Staphylocoous aureus (positive) ( NCTC 6571 ) and Escherichia coli (negative) ( NCTC 5933 ) . It was found that the concentration of ( 100 mg / ml ) of phenols was the highest activity where it recorded inhibition diameters equal to 22 mm and 20 mm for positive and negative bacteria respectively . Also the concentration of ( 100 mg / ml ) of the alkaloidic compound , showed the highest inhibition activity where it recorded inhibition diameters equal to 16 mm and 10 mm for positive and negative bacteria respectively . The minimal inhibitory concentrations (MIC) were estimated for phenols with value 25 mg / ml for both types of pathogenic bacteria and also for alkaloidic compound with values equal to 50 mg / ml and 75 mg / ml for pathogenic positive and negative bacteria respectively . As a result the alkalloidic compound and phenols are recommended to use them as medicinal substituents for treatment of skin infections instead of used antibiotics but this work demands further clinical studies | ||
| Keywords | ||
| Matricaria chamomilla; phenols; alkaloidic compound; Pathogenic bacteria; skin infections; medicinal activity | ||
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