Leptin Effect in the Development of Obesity –Related Hypertension in Postmenopausal Women | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 9, Issue 2, June 2010, Pages 155-157 PDF (0 K) | ||
| Author | ||
| Waleed Kh. Hussein | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Obesity in humans causes hypertension, myocardial hypertrophy and coronary atherosclerosis, and increased cardiovascular morbidity and mortality that is thought to be related to sympathetic overactivity. Leptin is an adipocyte-derived hormone that acts in the hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow. One of the major mechanisms leading to the development of obesity-induced hypertension appears to be leptin-mediated sympatho-activation. OBJECTIVE: This study is done to evaluate the contribution of leptin in the development of obesity related hypertension in post menopausal women. SUBJECTS AND METHODS: A total number of 64 subjects (post menopausal women) included in the study were divided into obese hypertensive group (n= 38 )and non obese non hypertensive group (n=26) , age(57+4.5year) and (56+2.7year) respectively(mean+SD). Obese hypertensive group defined as (BMI ≥ 30 kg/m2 and blood pressure ≥ 140/90 mmHg with or without history of taking anti hypertensive medications)and Non-obese non hypertensive group defined as (BMI < 30 kg/m2- blood pressure < 140/90 mmHg).In the present study leptin had been measured. RESULTS: Leptin level is higher in obese hypertensive group than in non obese non hypertensive group and it was 29.2+4 and 15.2+2.1(mean+SD) respectively and this difference is statistically significant with p value < 0.001. CONCLUSION : leptin may play a role in the development of obesity- related hypertension and may be an independent predictor of hypertension | ||
| Keywords | ||
| leptin; Obesity; Hypertension | ||
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