HLA antigen typing in patient with chronic uveitis & in patients with Behcet’s disease presenting with chronic uveitis | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 15, Issue 1, June 2012, Pages 320-325 | ||
| Authors | ||
| Dr.Hussein A. Fakhir Nafakhib; Dr Hassanain M. Ahmeda; Dr.Sabah N. Mohammedc | ||
| Abstract | ||
| Background: Uveitis is a significant cause of visual impairment and immune mechanisms are thought to be involved in the pathogenesis of disease. The main aim of this study is to find a relationship between specific HLA antigen pattern in patients with chronic uveitis and in patients with Behçet’s disease presenting with chronic uveitis in Iraqi patients. Patients and methods: A total number of 44 Iraqi patients (male=18 & female=26) with mean age 31,4 years that had been referred and examined at the ophthalmology center from January 2009 to march 2011 were enrolled in our study. Only 6 patients enrolled in the study (13,6%) fulfilled the criteria of Behçet’s disease according to international classifications. Results: There was no significant statistical association between HLA antigen and chronic uveitis in our study (p value = 0.98) and anterior uveitis occurred in about 24 patients (54.5%) and pan uveitis in 20 patients (45.5%) while intermediate uveitis was not diagnosed in our patients enrolled in this study. The 6 patients (13,6%) that fulfilled criteria for Behcet’s disease (3 with anterior uveitis and 3 with panuveitis) and all the patients showed strong association with HLA B51 which is the more prevalent antigen in the patients enrolled in this study (27%). | ||
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