Dose Dependent Anti-inflammatory Effect of Ammi majus Alcoholic Extract in Rat: Chronic Study | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 21, Issue 1, June 2012, Pages 82-86 | ||
| Author | ||
| Shihab H. Mutlag | ||
| Abstract | ||
| During treatment of inflammatory diseases, many conventional therapies (non-steroidal anti-inflammatory drugs) used to relief pain and inflammation. Chronic use of the intended drugs is frequently associated with serious side effect, which may lead to discontinuation of treatment . The efficacy and dose- response effect of ammi majus extraxt (2 , 4, 8 , 16, and 32 mg/rat) were assessed using formalin to induce paw edema in rats as a model of chronic inflammation respectively. In this study, 42 rats were used and allocated into 7 groups each containing 6 rats, representing control (Distilled water) , standard (piroxicam ) and test extract ( 2 , 4 , 8 , 16 and 32 mg/rat of Ammi majus alcoholic extract ). The test extract and control were given orally before induction of inflammation Paw edema was measured by using vernier caliper after 7 days for chronic inflammation. The result indicated that Ammi majus alcoholic extract significantly lower paw edema (p<0.05) compared to standard and control, while the dose 16mg/rat also lower the paw edema compared with other test groups but less compared with the dose 32mg/rat. In conclusion, Ammi majus alcoholic extract possess anti-inflammatory activity in animals model of chronic inflammation and the effect increased with increasing the dose. | ||
| Keywords | ||
| mmi majus alcoholic extract; Chronic inflammation; Dose; Dependent | ||
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