Biological Activity & Some Transition Elements Complexes For 1,3,4 Ox diazole Derivatives On Growth Of Some Pathogenic Bacteria | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 7, Issue 1, June 2012, Pages 22-34 PDF (0 K) | ||
| DOI: 10.32894/kujss.2012.44371 | ||
| Authors | ||
| Ferdos Mohamed Ali; Youssra Jaleel Ahmed | ||
| Abstract | ||
| In this research the biological activity studied of O-hydroxy benzoyl hydrazid (AY) which used to prepare 2-thiol-5(ortho-hydroxy phenyl) 1,3,4 oxadiazole and their derivatives as follow:first the L1 = 5- (ortho-hydroxy phenyl) –2- (acetyl methyl thio) 1,3,4 oxadiazole (AMTO) and The complexes of this ligand (L1) with transition metals ions (Cr+3,Mn+2,Fe+3,Co+2,Ni+2), against the growth of three bacteria taken from the microbiology labrotories at Azady hospital/kirkuk, these bacteria were: ) Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis). The proposed structures of the prepared chemical compounds and the prepared complexes were characterized and identified according to the elemental analysis (C.H.N), Infrared ,UV-visible spectroscopy, atomic absorption, magnetic susceptibility and molar conductivity techniques was studied. The investigation of biological activity of the prepared compounds tested using plate- Agar well diffusion method. The biological activity of the prepared compounds and complexes were found to be more effective than sulfadiazine that used as standered drug due to similar chemical structures of the prepared compounds and complexes which contains sulfur and nitrogen atoms, the minimum effective concentration of the prepared complexes was ( 25 ppm) while the minimum effective concentration of sulfadiazine were ( 100 ppm) . | ||
| Keywords | ||
| biological activity; Transition Elements; complexes; Ox diazole; Derivatives; Growth; Pathogenic bacteria | ||
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