S. Al-Ghabsha, T., M. Saeed, A. (2012). Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution. Alustath, 5(3), 13-17. doi: 10.37652/juaps.2011.44301
Thabit S. Al-Ghabsha; Amal M. Saeed. "Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution". Alustath, 5, 3, 2012, 13-17. doi: 10.37652/juaps.2011.44301
S. Al-Ghabsha, T., M. Saeed, A. (2012). 'Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution', Alustath, 5(3), pp. 13-17. doi: 10.37652/juaps.2011.44301
S. Al-Ghabsha, T., M. Saeed, A. Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution. Alustath, 2012; 5(3): 13-17. doi: 10.37652/juaps.2011.44301

Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin in Aqueous Solution

Journal of University of Anbar for Pure Science
Article 6, Volume 5, Issue 3, December 2011, Pages 13-17    PDF (300.08 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2011.44301
Authors
Thabit S. Al-Ghabsha; Amal M. Saeed*
University of Mosul - College of Education.
Abstract
A simple, rapid and sensitive spectrophotometric method for the determination of
noradrenaline was developed. The method is based on the proton transfer reaction with quinalizarin in
aqueous neutral solution to form a violet product showing maximum absorbance at 560 nm with molar
absorptivity of 6680 l.mol-1.cm-1. The method follows Beer’s law over the concentration range
(5.91×10-6 -5.91×10-5) mol.L-1 The accuracy (average recovery) of the method is 99.72% and the
precision (RSD) of the method is less than 1.5%.The method was successfully applied for the
determination of noradrenaline in pharmaceutical formulation as injection and the results were in a
good agreement with the standard addition procedure.
Keywords
Noradrenaline; Spectrophotometric method; Quinalizarin; Pharmaceutical Formulation
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