Synthesis of New Diazahomoadamantanone and Study the Reactivity of Carbonyl group | ||
Journal of University of Anbar for Pure Science | ||
Article 1, Volume 5, Issue 3, December 2011, Pages 1-4 PDF (318.84 K) | ||
Document Type: Research Paper | ||
DOI: 10.37652/juaps.2011.44297 | ||
Authors | ||
Ahmad H. Shukkur1; Kuznetsov A. I2; Serova T. M3 | ||
1University of Al-Anbar - College of Education for Pure Sciences | ||
2Lomonosov Academy of Fine Chemical Engineering, Moscow, Russia | ||
3Institute of Physiologically Active Substances, Russian Academy of Science, Russia. | ||
Abstract | ||
In this paper, new diazahomoadamantane was prepared by condensation of cyclic ketone (cyclododecanone) with 1,3,6,8-tetraazatricyclo[4.4.1.13,8]dodecane and acetic acid in 2-propanol gave new diazahomoadamantanone (13,16-diazatetracyclo-[9.6.1.11,13.111,16]eicosan-18-one) by Mannich,s reaction. Also were studied the reactivity of carbonyl group with various chemical agents like ( NaBH4 , H2N-NH2.H2O and NH2-OH.HCl). A simplified procedure was developed for the synthesis of 1,3,6,8-tetraazatricyclo [4.4.1.13,8]dodecane from condensation of ethane-1,2-diamine with paraform (Type A) in a very good yield. This new compound was characterized by FT-IR, Mass spectrum, 1H NMR and 13C NMR spectroscopy methods | ||
Keywords | ||
Mannich reaction; Ethane; diamine; Paraformaldehyde; Cyclododecanone; Diazahomoadamantanone | ||
References | ||
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