A Comparative Biochemical Study of Proteins Profile in Iraqi Children and Adolescent with â–Thalassemia | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 19, Issue 2, December 2010, Pages 19-23 | ||
| Authors | ||
| Zeinab M. Al-Rubaei; Nawal MJ Al-Shammaa; Emad M. Malik; Ali M. Malik | ||
| Abstract | ||
| The aim of the present research is to study different protein fractions in sera of children and adolescent with â –thalassemia major and minor and to compare the results with that of healthy control.One hundred fifty children and adolescents were enrolled in this study,including 50 patients with â- thalassemia major , 50 patients with â- thalassemia minor as pathological control group and another apparently 50 healthy individuals as a control group. The age of all studied groups ranged from (4-18)years.Total protein, albumin and immunoglobulins were estimated in sera of all subjects. A Significant decrease was found in the total protein and albumin levels in sera of both major and minor thalassemic patients compared to normal groups. A Significant increase in immunoglobulin levels (IgG, IgM and IgA) was found in the sera of major and minor â-thalassemia patients compared to control.Different protein parts in sera of all subjects were detected using cellulose acetate electrophoresis.The results revealed significant reduction in â- globulin fractions in â- thalassemia major patients compared to the normal and pathological control groups. Significant elevations in م- globulins fractions were observed in both major â- thalassemia and minor â- thalassemia as compared to normal control group. As a Conclusion the alteration in some protein parts occurred which is more obvious in major thalassemia patients compared to the normal and pathological control groups. | ||
| Keywords | ||
| Protein Parts; Elecrtrophoresis; Thalassemia | ||
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