the effect of Radiotherapy and Chemotherapy in several Physiologyical and Biochemical Parameters in cancer patients | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 1, March 2012, Pages 83-91 | ||
| Author | ||
| HalaHashim Daham | ||
| Abstract | ||
| The current study addressed the effect of chemotherapy and radiotherapy on some physiological and biochemical aspects in Cancer patients, 113 patients (18-75 years old) whom reviewing hospital oncology and nuclear medicine in Mosul for the period from the beginning of November (2008) to the end of March (2009) were divided into groups based on the type of treatment . These groups were : Chemotherapy ,Radiotherapy ,chemo-radiotherapy,non-treated ,control group (30 )The study showed a decrease in concentration of Hemoglobin (%Hb) , Packed Red cells volume (PCV) and Platelets in non-treated patients compared with control , such decrease was also observed in chemotherapy and chemo-radiotherapy groups , while an increase in Hemoglobin and platelet was showed in Radiotherapy group compared to non-treated groups . No significant difference in total count of Leucocytes observed between the non-treated group .In comparison with the control, an increase in malondialdehyde (MDA) concentration and a decrease in glutathione (GSH) concentration were observed in case of non-treated groups . (MDA) concentration were decreased in all treated groups compared with non-treated one while an increase in (GSH) concentration was observed in both radiotherapy and chemo radiotherapy groups compared with non-treated group.Concerning the Cholesterol concentration , it was increased in non-treated groups compared to control No significant differences were shown between chemotherapy group and non-treated one while both radiotherapy and chemo-radiotherapy groups showed an increase in concentration of cholesterol compared with non-treated group .An increased concentration of triglycerides (TG) was observed in non-treated group compared with control . Also it increased in case of chemotherapy and chemo-radiotherapy groups compared with non-treated while a decrease in (TG) concentration was observed in case of radiotherapy compared with non-treated group | ||
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