The Effect of Profen and Vitamin C on rate of Sperm abnormalties and Weight of | ||
| JOURNAL OF THI-QAR SCIENCE | ||
| Article 1, Volume 3, Issue 2, June 2013, Pages 25-32 | ||
| Author | ||
| Aseel Raheem Mardan | ||
| Abstract | ||
| Abstract : The present research was conducted on 36 white mice of similar weights by using one of the nonsteroid anti-inflammation drugs, namely profen. Vitamin C was used to assess the sperm abnormality; the testes mean weight, and prostate gland weight. The mice were divided into three equal groups. The mice of the first group were injected with profen (200mg. /kg. for each), the second was injected with profen and vitamin C (200mg. /kg. for each), and the third group was the control one. The mice of the first two groups were injected, in the peritoneum membrane once a day for a month. The treatment with profen resulted into an increase in the percentage of the abnormal sperms compared to the control group (10.74 ± 1.92 and 4.17 ± 1.26 respectively). The results have shown that the treatment with vitamin C and profen led to a decrease in the percentage of the abnormal sperms compared to the profen group (10.74 ± 1.92). The statistical analysis has shown considerable differences (P< 0.05) for this group compared to the control one; this means that the use of vitamin C with profen decreases the percentage of abnormality effected by profen. Also, there happened a considerable decrease (P< 0.05) in the testes weight treated with profen (2526.8 ± 6.48 mg.) compared to the control group (3203 ± 9.9 mg.). However, the testes weight was high in the group treated with profen and vitamin C (3245.5 ± 13.8 mg.) compared to the profen group. In addition, there were no considerable statistical differences between the control group and the profen and vitamin C group. As for the prostate gland, there was a considerable decrease (P<0.05) in the weight when treated with profen (890 ± 9.3 mg.) compared to the control group (896 ± 9.9 mg.). Furthermore, there were no statistically considerable differences (P< 0.05) between the profen and vitamin C group (900 ± 9.0 mg.) compared to the control and profen groups. | ||
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