Spectrofluorimetric method for the determination of glibenclamide in pharmaceutical formulations | ||
Baghdad Science Journal | ||
Article 1, Volume 9, Issue 2, June 2012, Pages 296-301 | ||
Authors | ||
Perween A. Hassen; Karim D. Khalaf | ||
Abstract | ||
A sensitive spectrofluorimetric method for the determination of glibenclamide in its tablet formulations has been proposed. The method is based on the dissolving of glibenclamide in absolute ethanol and measuring the native fluorescence at 354 nm after excitation at 302 nm. Beers law is obeyed in the concentration of 1.4 to 10 µg.ml-1 of glibenclamide with a limit of detection (LD) of 0.067 µg.ml-1 and a standard deviation of 0.614. The range percent recoveries (N=3) is 94 - 103. | ||
Keywords | ||
Glibenclamide; spectrofluorimetric | ||
Statistics Article View: 144 PDF Download: 121 |