Evaluation of Amino acid Homocysteine in Hypertensive Patients | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 5, Issue 2, June 2006, Pages 151-154 PDF (0 K) | ||
| Author | ||
| Ali Taqi. Al-Baldawi | ||
| Abstract | ||
| ABSTRACT : BACKGROUND : Hypertension is a world wide disease and in 90% of cases the cause is unknown . Its early detection and treatment can prevent serious complications such as ischemic heart disease (IHD) . Furthermore the association of lipids with IHD is a well-known fact . However abnormally high levels of homocysteine were found to be strongly linked to an increase risk of coronary artery disease . OBJECTIVES: To evaluate the total plasma homocysteine concentration in hypertensive patients. METHODS : Total plasma homocystein concentrations were measured using High Performance Liquid Chromatography(HPLC) with Ultraviolet( UV) detector in 60 hypertensive patients (27 male and 33 female) aged 35 years and more . Cholesterol , triglyceride , HDL-cholesterol , LDL-cholesterol , VLDL-cholesterol were determined .The prevalence of high total homocysteine values were determined by comparison with normal reference population. RESULTS : Total plasma homocysteine levels were significantly higher in patients than in normal population. Total serum cholesterol and triglyceride concentrations were also significantly higher in patients than in normal population with no association to the level of homocysteine which is regarded as a special independent vascular risk factor. CONCLUSION : The study involves the evaluation of homocysteine in hypertensive patients plasma homocysteine levels were significantly higher in patients than in control groups. There were no significant differences between male and female patients. | ||
| Keywords | ||
| Atherosclerosis; homocysteine; Hypertension; Ischemic heart disease | ||
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