INDUCTION OF ICAM-1 AND ICAM-3 IN WOMEN WITH RECURRENT PREGNANCY LOSS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 6, Issue 2, August 2008, Pages 103-109 | ||
| Authors | ||
| Haider Faisal Ghazi; Baqer Al-Obaidi; ; Nidhal Abdul Mohymen | ||
| Abstract | ||
| Recurrent pregnancy loss (RPL) has been found to be associated with increase in the pro-inflammatory cytokines which cause up-regulation of inflammatory mediators including cell adhesion molecules (CAMs) that might act in aggravation of this pathological process. Objective: To find out whether there is a relation between the pathology of RPL and the expression of intracellular adhesion molecule-1 (ICAM-1) and ICAM-3 at the feto-maternal interface in these patients. Methods: Immunohistochemistry technique was performed to detect and determine the expression of ICAM-1 and ICAM-3 using paraffin embedded sections of curate samples obtained from 40 women, who where divided into three groups: 24 women with RPL, 10 women with abortion for the first time, and 6 women with induced abortion. Results: The levels of the expression of both endothelial ICAM-1 and leukocytes ICAM-3 at the feto-maternal interface were found to be significantly up-regulated in the first group as compared with the second and the third groups (p=0.001), with a highly significant positive correlation between these two parameters (r=0.927, p<0.01). Conclusion: ICAM-1 and ICAM-3 might play an important role in the pathology of RPL by increase adherence and recruitment of inflammatory cells at the feto-maternal interface ending with a pregnancy failure | ||
| Keywords | ||
| Inter Cellular Adhesion Molecule; ICAM; and Inter Cellular Adhesion Molecule; Recurrent pregnancy loss | ||
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