Isolation and Studying some Extracts, Protenious and non-protenious Compounds from Sweet Majorum (Origanum majorana) in Mice Exposed to Oxidative Stress | ||
| Rafidain Journal of Science | ||
| Article 10, Volume 22, Issue 4, June 2011, Pages 129-144 PDF (0 K) | ||
| DOI: 10.33899/rjs.2011.31544 | ||
| Author | ||
| Sakena H. Rashed | ||
| Abstract | ||
| This study was designed to prepare cold aqueous extracts of Origanum majorana fruits, and isolation of alkaloid and flavonoids extracts. The study also comprised the isolation and studying the proteinous compounds, using gel filtration technique. Two compounds were separated A (233646 M.wt) Dalton and B(1032 M.wt) Dalton from the cold proteinous precipitate. The effects of these extracts and the compounds previous mentioned above were studied on serum glucose and total cholesterol. Also glutathione (GSH) and malondialdehyde (MDA) levels in liver, kidney and heart tissues in mice exposed to oxidative stress. The extracts were administrated intraperitoneally . After one week from the treatment, the results were indicated that the cold crude aqueous, non-proteinous extracts, alkaloids, flavonoids, proteinous precipitate and proteinous compound B which was isolated from it at the doses of (400, 400, 0.51, 0.33, 10.15, 2.58) mg/kg body weights caused a significant decrease (p<0.05) in serum glucose, total cholesterol and MDA level in liver, kidney and heart tissues, also caused significant increase (p<0.05) in GSH level in liver, kidney and heart tissues in male mice exposed to oxidative stress. The study concluded that most Origanum Majorana extracts have antioxidant effect in mice exposed to oxidative stress . | ||
| Keywords | ||
| Origanum Majorana; Antioxidants; Glucose; Cholesterol | ||
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